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Care365 medication guide
Simvastatin
Lowers cholesterol and reduces cardiovascular risk in eligible patients.
Drug information
Uses, directions and safety information for Simvastatin.
What it is used for
Lowers cholesterol and reduces cardiovascular risk in eligible patients.
How to use it
Usually taken in the evening. Do not increase to 80 mg without specialist review because muscle toxicity risk is higher.
Before use
Avoid active liver disease and contraindicated combinations.
Possible side effects
Abdominal discomfort, constipation and gas.
When to get medical help
Muscle weakness with dark urine or jaundice needs prompt assessment.
Medicines and interactions
Strong CYP3A4 inhibitors, gemfibrozil, cyclosporine and several heart medicines require avoidance or dose limits.
Pregnancy and breastfeeding
The Canadian reference contraindicates pregnancy and breastfeeding.
Missed doses, storage and accidental exposure
Follow your own product’s missed-dose instructions. If you are unsure, ask a pharmacist before taking an extra dose. Contraceptives, injections and modified-release medicines may need a specific plan.
Keep the original packaging and follow its storage, expiry and disposal instructions. Keep medicines away from children and pets. Ask about refrigeration, after-opening limits and safe sharps disposal when relevant.
For suspected overdose or accidental swallowing, contact poison control or urgent medical care promptly. Call emergency services for breathing difficulty, collapse or a seizure.
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Explore care for your symptoms and prepare for a conversation about treatment. Your healthcare professional will consider your history, current medicines and whether an assessment or referral is appropriate.
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A healthcare professional assesses which care or referral is appropriate.
Plan your follow-up
Follow the advice you receive about treatment, monitoring and next steps.
Related condition guides
Learn about concerns where this medication may be discussed. Treatment depends on your individual assessment.
Prescription renewal and medication review
For a review of Simvastatin, have your current dose, reason for treatment, remaining supply, benefits, side effects and pharmacy details ready. Ask your pharmacist or prescriber whether a renewal assessment is available and appropriate. A prescription or renewal is not guaranteed.
Questions about Simvastatin
What is Simvastatin used for?
Lowers cholesterol and reduces cardiovascular risk in eligible patients.
How should I use Simvastatin?
Usually taken in the evening. Do not increase to 80 mg without specialist review because muscle toxicity risk is higher.
What side effects can Simvastatin cause?
Abdominal discomfort, constipation and gas.
When should I get medical help while using Simvastatin?
Muscle weakness with dark urine or jaundice needs prompt assessment.
Can Simvastatin interact with other medicines?
Strong CYP3A4 inhibitors, gemfibrozil, cyclosporine and several heart medicines require avoidance or dose limits.
What should I know about Simvastatin during pregnancy or breastfeeding?
The Canadian reference contraindicates pregnancy and breastfeeding.
Sources and product information
Sources checked 2026-09-08. Safety sections are highlights; consult the full product information for complete warnings and instructions.
Check the Canadian Drug Product Database by product name or DIN for current product information.
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