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Care365 medication guide
Naltrexone/bupropion
Supports weight management in eligible adults.
Drug information
Uses, directions and safety information for Naltrexone/bupropion.
What it is used for
Supports weight management in eligible adults.
How to use it
Dose increases gradually over four weeks. Swallow whole; reassess response after 12 weeks at maintenance.
Before use
Avoid opioid use, seizure/eating disorders, uncontrolled hypertension, other bupropion and abrupt sedative or alcohol withdrawal.
Possible side effects
Nausea, constipation and vomiting.
When to get medical help
Seizures or suicidal thoughts need urgent help; monitor blood pressure.
Medicines and interactions
MAOIs and many medicines interact. Do not attempt to overcome opioid blockade with extra opioids.
Pregnancy and breastfeeding
Do not use during pregnancy or breastfeeding.
Missed doses, storage and accidental exposure
Follow your own product’s missed-dose instructions. If you are unsure, ask a pharmacist before taking an extra dose. Contraceptives, injections and modified-release medicines may need a specific plan.
Keep the original packaging and follow its storage, expiry and disposal instructions. Keep medicines away from children and pets. Ask about refrigeration, after-opening limits and safe sharps disposal when relevant.
For suspected overdose or accidental swallowing, contact poison control or urgent medical care promptly. Call emergency services for breathing difficulty, collapse or a seizure.
Care that starts with a conversation
How Care365 can help
Explore care for your symptoms and prepare for a conversation about treatment. Your healthcare professional will consider your history, current medicines and whether an assessment or referral is appropriate.
Your next steps
Know what to prepare and what to discuss.
Share your history
Prepare your symptoms, allergies, medication list and treatment questions.
Discuss your options
A healthcare professional assesses which care or referral is appropriate.
Plan your follow-up
Follow the advice you receive about treatment, monitoring and next steps.
Related condition guides
Learn about concerns where this medication may be discussed. Treatment depends on your individual assessment.
Prescription renewal and medication review
For a review of Naltrexone/bupropion, have your current dose, reason for treatment, remaining supply, benefits, side effects and pharmacy details ready. Ask your pharmacist or prescriber whether a renewal assessment is available and appropriate. A prescription or renewal is not guaranteed.
Questions about Naltrexone/bupropion
What is Naltrexone/bupropion used for?
Supports weight management in eligible adults.
How should I use Naltrexone/bupropion?
Dose increases gradually over four weeks. Swallow whole; reassess response after 12 weeks at maintenance.
What side effects can Naltrexone/bupropion cause?
Nausea, constipation and vomiting.
When should I get medical help while using Naltrexone/bupropion?
Seizures or suicidal thoughts need urgent help; monitor blood pressure.
Can Naltrexone/bupropion interact with other medicines?
MAOIs and many medicines interact. Do not attempt to overcome opioid blockade with extra opioids.
What should I know about Naltrexone/bupropion during pregnancy or breastfeeding?
Do not use during pregnancy or breastfeeding.
Sources and product information
Sources checked 2026-09-08. Safety sections are highlights; consult the full product information for complete warnings and instructions.
Check the Canadian Drug Product Database by product name or DIN for current product information.
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